![hippocampus anatomy landmarks hippocampus anatomy landmarks](https://image.shutterstock.com/image-vector/brain-anatomy-human-lateral-view-600w-168732359.jpg)
(1994) and Buckmaster and Schwartzkroin (1994), it has been proposed that mossy cells receive excitatory inputs from granule cells and CA3c pyramidal cells and integrate A picture of the subdivisions of the CA3 region based on the work of Lorente de Nó is shown in Figure 1. It has been shown that the CA3 region can be divided into CA3a, b, and c subareas ( Lorente de Nó 1934 Li et al.
![hippocampus anatomy landmarks hippocampus anatomy landmarks](https://media.springernature.com/lw685/springer-static/image/art%3A10.1203%2F00006450-200107000-00022/MediaObjects/41390_2001_Article_BFpr2001158_Fig1_HTML.jpg)
The hippocampus ( Amaral and Witter 1995). The medial septum and vertical limb of the diagonal band of Broca, in turn, provide cholinergic and GABAergic inputs into 1991 Amaral and Witter 1995 Risold and Swanson 1997). Reported that CA3 projects to the lateral and medial septal nuclei as well as to the vertical limb of the diagonal band ofīroca ( Gaykema et al. In addition to the projections originating in CA1, projections out of Ammon’s horn originate in CA3. Lateral entorhinal cortex, mossy fiber inputs from the dentate gyrus, and its own outputs fed back as inputs via the recurrentĬollaterals ( Amaral and Witter 1995). CA3 also receives converging inputs from multiple input pathways for example, perforant path inputs from the medial and The most prominent anatomical feature of the CA3 subregion is that there are extensive interconnections among the principalĬells via a recurrent collateral fiber system ( Amaral and Witter 1995). Medial and lateral entorhinal cortex) as well as outputs from CA3 to brain regions within the hippocampus (i.e., dentate gyrus,ĬA1) and brain regions outside the hippocampus (i.e., medial and lateral septum). In the third section, I emphasize that the mnemonic functions of the autoassociative network of CA3 depend on inputs intoĬA3 from other brain regions within the hippocampus (i.e., dentate gyrus) and brain regions outside the hippocampus (i.e., Spatial information represents the critical attribute or domain that is processed in CA3. Finally, CA3c may contribute to pattern separation Memory retrieval as evidenced by support for a pattern completion process. It should be noted that CA3a,b can also be involved in short-term Multiple trials to construct relational representations. Also, CA3a,b mediates encoding of information requiring In the context of short-term memory, the CA3a,b mediates rapid encoding of especially spatial information, noveltyĭetection, and one-trial cued recall (all forms of episodic memory). That CA3a,b mediates the acquisition and encoding of spatial information within short-term memory with a duration of secondsĪnd minutes. In the second section, I present the influence ofĪn autoassociative network function of the CA3 region in supporting mnemonic functions. Section, I present a general overview of the anatomy of the hippocampus. This review article emphasizes the importance of behavioral functions of the CA3 subregion of the hippocampus. Finally, CA3c may, in cooperation with the dentate gyrus, serve an important role in processing the geometry of the The CA3a,b also supports retrieval of short-term memory information based on a spatial pattern completion The CA3a,bĪlso plays a role in sequential processing of information in cooperation with CA1 based on the Schaffer collateral outputįrom CA3a,b to CA1. Perforant path inputs play a supporting role in the neural circuit that supports the operation of these tasks. The output from CA3a,b via the fimbria and the medial and lateral Within an autoassociative network function of the CA3 region. Tend to be non-episodic and can be mediated by arbitrary and conjunctive operations.
![hippocampus anatomy landmarks hippocampus anatomy landmarks](https://nba.uth.tmc.edu/neuroscience/m/s4/images/copyright_marked_images/html5/5-3_NEW.jpg)
Spatial information requiring multiple trials including the acquisition of arbitrary and relational associations. The CA3a,b is also important for encoding of These are tasks that have been assumed to reflect the operations of episodic memory and require interactionsīetween CA3a,b and the dentate gyrus via mossy fiber inputs into the CA3a,b. Rapid encoding, novelty detection, one-trial short-term or working memory, and one-trial cued recall primarily for spatial This can easily be observed in tasks that require Information within short-term memory with a duration of seconds and minutes. From a behavioral perspective, the CA3a,b subregion of the hippocampus plays an important role in the encoding of new spatial